To compare the incidence of acute kidney injury (AKI) post percutaneous coronary intervention (PCI) in a Dapagliflozin treated group versus a group managed with the usual standard of care.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
250
One tablet daily starting 48h prior to PCI and continuing for 48h post-PCI.
Einstein Medical Center
Philadelphia, Pennsylvania, United States
Acute Kidney Injury
According to the Kidney Disease Improving Global Outcomes (KDIGO) 2012 definition: increase in serum creatinine by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48 hours or increase in serum creatinine (SCr) to ≥ 1.5 times the known baseline which is known or presumed to have occurred within the prior 7 days. We will measure Urine Neutrophil Gelatinase-associated Lipocalin (UNGAL) at least 6 hours post-PCI and Serum Creatinine at follow up within 7 days.
Time frame: Within 7 days.
Length of hospital stay
Days
Time frame: 7 days
Incidence of genitourinary infections
Symptomatic pyuria or new vaginal infection.
Time frame: 7 days
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