Cardiac Output in Preeclamptic

Mansoura University34 enrolled

Overview

There is high incidence of hypertensive disorders during pregnancy.The maternal cardiovascular system had significant changes during pregnancy. The colloid oncotic pressure is decreased during preeclampsia.

Transthoracic echocardiography considered an accurate non-invasive device and has validity for measuring cardiac functions in pregnancy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Echocardiography

Interventions

1000 mL of ringer's acetate solutionDRUG

1000 mL of ringer's acetate solution

250 mL 6% hydroxyethyl starch (Voluven) then 500 mL of ringer's acetate solution then 250 mL of 6% hydroxyethyl starch (Voluven)DRUG

500 mL 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride plus 500 mL of ringer's acetate solution

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pre-eclampsia * Age 18-45 years. * Singleton pregnancy scheduled for elective CS delivery under spinal anesthesia. * American Society of Anesthesiologists (ASA Ⅱ, Ⅲ). Exclusion Criteria: * Body mass index \< 18 or ≥40 kg/m² * Women presenting in labor * Current administration of vasoactive drugs including salbutamol and thyroxin. * Diabetes mellitus. * Hemoglobin \<10 g/dl. * Cardiovascular, cerebrovascular, or renal disease * Increased serum creatinine level ≥1.1 mg/dL. * Contraindications to spinal anesthesia:(increased intracranial pressure, coagulopathy, or local skin infection)

Locations (1)

Mansoura University-Emergency hospital-ICU

Al Mansurah, Mansoura, Egypt

Outcomes

Primary Outcomes

Cardiac output measurement

1 hour post spinal anesthesia after administration of 1000 mL fluid using Transthoracic Echocardiography

Time frame: 1 hour from the spinal anesthesia

Secondary Outcomes

Cardiac output measurement

at baseline ,5 minutes after spinal anesthesia, after delivery of the fetus and 2 hours post spinal anesthesia

Time frame: 5 minutes after the spinal anesthesia, after delivery of the fetus and 2 hours post spinal anesthesia

Left ventricular end diastolic volume (LVEDV) measurement

milliliter

Time frame: 1 hour from the spinal anesthesia

Urine output volume

milliliters

Time frame: 1hour and 2 hours post spinal anesthesia

Heart rate (HR)

beats per minute

Time frame: basal (preoperative), intraoperative each 10 minutes and postoperatively every hour during first 6 hours

Mean Blood pressure

mmHg

Time frame: basal (preoperative), intraoperative each 10 minutes and postoperatively every hour during first 6 hours

Data from ClinicalTrials.gov

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