Fractional Laser Versus Radiofrequency in Androgenetic Alopecia

Kasr El Aini Hospital30 enrolled

Overview

Patients with Androgenetic alopecia will be randomized into 2 groups; Group FCO2 receiving Fractional CO2 or Group FRF receiving Fractional Microneedling Radiofrequency.

Group FCO2 will be to receiving fractional CO2 to one randomized side of the scalp, and Group FRF will be receiving Fractional Microneedling radiofrequency to one randomized side of the scalp. All patients will receive 4 sessions with 4-week intervals.each session will be followed by immediate topical application of 6 puffs (=1 mL) of minoxidil 5% solution twice daily and also in between the sessions and during follow up period

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Androgenic Alopecia

Interventions

FCO2PROCEDURE

Fractional Carbon dioxide laser

FRFPROCEDURE

Fractional Microneedling Radiofrequency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * • both genders are included. * Patients above 18 years old. Exclusion Criteria: * • Patients with patchy hair loss. * Patients with Telogen Effluvium or diffuse alopecia areata. * Patients with cicatricial alopecias. * Patients with associated inflammatory scalp disorders such as psoriasis or seborrheic dermatitis. * Patients with collagen vascular disorders. * Prior use of topical steroids on scalp in the previous 2 weeks. * Prior use of systemic steroids in the previous 1 month.

Locations (1)

Kasr Al Ainy Hospital

Cairo, El Manial, Egypt

RECRUITING

Outcomes

Primary Outcomes

Clinical Global improvement Assessment

Photographs will be taken with a Canon camera under controlled light in approximately the same position, taken at baseline, after 4 treatment sessions (16 weeks post treatment) and 2 months after follow-up (24 weeks post treatment). First clinical assessment will be performed based on the clinical change from baseline at 16 weeks post treatment. Change in the clinical will be measured on a 6 point scale; (-1) worsening, (0) no improvement, (1) less than 25% improvement, (2) 25-50% improvement, (3) 50-75% improvement, (4) more than 75% improvement. A higher numerical means a better outcome.

Time frame: 6months-1 year

Clinical Global improvement Assessment

Photographs will be taken with a Canon camera under controlled light in approximately the same position, taken at baseline, after 4 treatment sessions (16 weeks post treatment) and 2 months after follow-up (24 weeks post treatment). Second clinical assessment will be performed based on the clinical change from 16 weeks post treatment to 24 weeks post treatment. Change in the clinical will be measured on a 6 point scale; (-1) worsening, (0) no improvement, (1) less than 25% improvement, (2) 25-50% improvement, (3) 50-75% improvement, (4) more than 75% improvement. A higher numerical means a better outcome.

Time frame: 6months-1 year

Phototrichogram assessment.

A phototrichogram system (Dino-Lite; AnMo Electronics, Taiwan)will be used to evaluate the number of hairs. A higher numerical means a better outcome.

Time frame: months-1 year

Phototrichogram assessment.

A phototrichogram system (Dino-Lite; AnMo Electronics, Taiwan)will be used to evaluate the thickness of hairs. A higher numerical means a better outcome.

Time frame: 2 months

Patient satisfaction

Participants will be also asked to give their assessment on a scale of 4, (0) no satisfaction (1) slight satisfation, (2) moderate satisfaction, (3) marked satisfaction. A higher numerical means a better outcome.

Central Contacts

Rana Hilal, MD

CONTACT

2010014888 rana.hilal@kasralainy.edu.eg

Data from ClinicalTrials.gov

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