"Escape" Phenomenon of the Antihypertensive Therapy Efficacy

Federal State Budgetary Institution NATIONAL MEDICAL RESEARCH CENTRE OF CARDIOLOGY NAMED AFTER ACADE165 enrolled

Overview

A little attention is paid to the AHT efficacy escaping problem, which can be explained by the AHT correction simplicity and rapid achievement of the target BP level. Nevertheless, modern statistic data on the effective AH treatment described above let us assume that AHT correction is either totally absent or is untimely in case of the "escape" phenomenon development. This could be one of the main reasons for the high prevalence of ineffective AH treatment. The aim of this study is to determine AHT efficacy "escape" phenomenon timeline and its predictors in hypertensive patients.

Study Type

OBSERVATIONAL

Enrollment

165

Conditions

Arterial Hypertension

Interventions

Ambulatory blood pressure measurement deviceDEVICE

Assessment of the 24-h blood pressure profile

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Arterial hypertension (AH) grade 1-3, stage I-II * High compliance during the follow-up period (≥ 85%) * Initially achieved target office BP levels while taking 2-3-component AHT Exclusion Criteria: * Secondary AH * Resistant AH, * AH III stage, * PAP- therapy, * type 2 diabetes mellitus, * pregnancy * history of low adherence to treatment

Outcomes

Primary Outcomes

Assessment of BP increasing higher the target level when taking the same therapy

Assessment of attenuation of efficacy of previously adequate antihypertensive therapy by using different BP measurement methods

Time frame: 1-6 months

Secondary Outcomes

Disease course: assessment of major CVE and death occurrence

Assessment of the disease course depending on the characteristics of 3-6th months of observation

Time frame: 10 years