Evaluating PVI Using CMR

Amsterdam UMC, location VUmc40 enrolled

Overview

Using state of the art cardiac magnetic resonance imaging techniques, characterization of ablation lesions in the early phase after pulmonary vein isolation ablation in atrial fibrillation patients, and relate findings to the ablation scar at 3 months follow up and atrial fibrillation-free survival at 1 year.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Atrial Fibrillation

Interventions

MRIPROCEDURE

MRI prior to PVI, acutely after PVI, and 3 months after PVI

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (age ≥18 years old) * Paroxysmal or persistent AF meeting guideline criteria. * Anticipated PVI using index-guided radiofrequency ablation techniques. * Availability of LGE-CMR images within 3 months before anticipated PVI. Exclusion Criteria: * History of catheter ablation * History of cardiac surgery. * History of chest radiation therapy * Estimated glomerular filtration rate (eGFR) \<45 ml/min/kg * Known (or suspected) allergic reaction to gadolinium * Contraindications for CMR (such as claustrophobia, certain implants, devices, high body mass index). * Inability to schedule CMR \<48h after PVI * Long-term use of anti-inflammatory medication, except for the use of nonsteroidal anti-inflammatory drugs * Autoimmune disease or chronic inflammatory illness. * Pregnancy of breast feeding

Outcomes

Primary Outcomes

Ablaton scar

The correlation between ablation lesion characteristics in the early phase after PVI and ablation scar at 3 months follow up.

Time frame: 3 months

Secondary Outcomes

AF recurrence

The relation between ablation lesion characteristics and AF recurrence at 1 year after the ablation procedure

Time frame: 1 year

Data from ClinicalTrials.gov

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