This study is a phase 1B/2 open-label, study to determine safety and preliminary efficacy of Q702 in combination with pembrolizumab in study subjects with advanced esophageal, gastric/GEJ, hepatocellular, and cervical cancers.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
The study drug Q702 will be administered once daily by mouth on Days 1 through 7, Days 15 through 21 and Days 29 through 35 of every treatment cycle.
Pembrolizumab will be administered using IV infusion on Day 1 of each 3-week treatment cycle
University of Southern California
Los Angeles, California, United States
RECRUITINGNorton Cancer Institute
Louisville, Kentucky, United States
RECRUITINGCHA Bundang Medical Center
Seongnam-si, South Korea
Number of participants with treatment-related adverse events as assessed by CTCAE
Time frame: Up to approximately 2 years (Each Cycle is 42 Days)
Tumor response using RECIST version 1.1 throughout study
Time frame: Up to approximately 2 years (Each Cycle is 42 Days)
Change in the area under curve (AUC) of Q702 and its primary metabolites
Time frame: Cycle 1 Day 1 and Day 22 (Each Cycle is 42 Days)
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Asan Medical Center
Seoul, South Korea
NOT_YET_RECRUITINGSamsung Medical Center
Seoul, South Korea
RECRUITINGSeoul National University Hospital
Seoul, South Korea
RECRUITINGSeverance Hospital
Seoul, South Korea
RECRUITING