The aim of this study is to evaluate efficacy of bovine colostrum administration as a prophylaxis to decrease the incidence and the occurrence of retinopathy of prematurity in preterm neonates of gestational age less than 32 weeks during their hospital stay.
This study will include a randomized controlled trial carried out on preterm neonates who will fulfill the eligibility criteria delivered at Alexandria University Children's Hospital. Evaluation of the outcome will be done only for those who admitted to the neonatal intensive care unit (NICU) at Alexandria University Children's Hospital. The study will be carried out in 4 phases: 1. First phase: Enrollment and selection phase. 2. Second phase: Intervention phase ( enteral bovine colostrum administration) . 3. Third phase: Evaluation phase. 4. Fourth phase: collected data analysis and results.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
200
The bovine colostrum sachets will be used in a dose of 3.5ml/kg/ day , starting from the first 3 days after birth, for 14 days. Enteral route, either through nasogastric tube or orally.
distilled water with no bovine colostrum
Alexandria university, Elshattbi hospital
Alexandria, Egypt
Marwa Mohamed Farag
Alexandria, Egypt
Fundus examination to detect retinopathy of prematurity
ROP screen will be performed by ophthalmologist to detect zone stage extension and severity of the disease
Time frame: 28 days
prematurity related complications
* late onset sepsis * IVH * Necrotizing enterocolitis * bronchopulmonary dysplasia
Time frame: 28 days
Assessment of weight
-Assessment of weight every other day.
Time frame: 28 days
-Assessment of Head circumference
measurement of Head circumference weekly.
Time frame: 28 days
-Assessment of length
-Assessment of length on admission and on discharge.
Time frame: 28 days
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