The main purpose of this study is to measure how much of Imlunestrant (LY3484356) gets into the bloodstream and how long it takes the body to eliminate it in female participants with impaired liver function compared to female participants with normal liver function. The side effects and tolerability of Imlunestrant will also be evaluated. The study may last up to 46 days for each participant.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
27
Administered orally.
Inland Empire Liver Foundation
Rialto, California, United States
Orlando Clinical Research Center
Orlando, Florida, United States
American Research Corporation at Texas Liver Institute
San Antonio, Texas, United States
Pharmacokinetics (PK): Maximum Observed Concentration (Cmax) of Imlunestrant
PK: Cmax of Imlunestrant is reported.
Time frame: Day 1 (Predose, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216, 240 hours post dose)
PK: Area Under the Concentration-time Curve From 0 to the Last Measurable Concentration (AUC[0-t]) of Imlunestrant
AUC(0-t) of Imlunestrant is reported.
Time frame: Day 1 (Predose, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48, 72, 96, 120, 144, 168, 192, 216, 240 hours post dose)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.