Evaluation of Different Colorectal Cancer Screening Strategies

Inclusion Criteria: * 50-74 years old * Informed consent is available Exclusion Criteria: * Previous colorectal cancer * Previous colorectal resection * Previous received cancer-related treatment (except non-melanoma skin cancer) * Colonoscopy, sigmoidoscopy, CT colonoscopy, and barium enema were performed within 5 years * Fecal occult blood or fecal DNA was performed within one year * Symptoms of lower digestive tract diseases requiring colonoscopy include: (1) rectal bleeding occurred more than once in the past 6 months, (2) recorded iron deficiency anemia, and (3) recorded significant weight loss within 6 months (\> 10% of baseline weight) * Suffering from other diseases that affect the benefit of screening or intolerance to colonoscopy (for example, severe pulmonary disease, end-stage renal disease, end-stage liver disease, severe heart failure or recently diagnosed cancer, except non-melanoma skin cancer)