Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS

N/ACompletedNCT05442073

Peking Union Medical College Hospital18 enrolled

Overview

Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ARDS, Human PEEP, Occult Esophageal and Pleural Pressure

Interventions

PEEP adjustmentOTHER

adjusting PEEP about 3-5cmH2O (increase or decrease)

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- aged over 18 all the moderate to severe ARDS patients invasive mechanical ventilation Exclusion Criteria: * aged\<18 contraindication to esophageal catheter

Locations (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

the changes of esophageal pressure during the PEEP titration

Time frame: March 1st to May 31st, 2022

Data from ClinicalTrials.gov

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