Effect of Sarcopenia on HCC After Lenvatinib and Anti-PD-1 Treatment

First Affiliated Hospital of Wenzhou Medical University200 enrolled

Overview

Sarcopenia is associated with the prognosis of HCC and cholangiocarcinoma. But there has been rare study focusing on the effect of sarcopenia on the prognosis of HCC treated with lenvatinib and anti-PD1.

By tracking the short-term and long-term results of HCC patients treated with lenvatinib and anti-PD1,the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after systemic treatment was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes, the differences were analyzed and the relationship between sarcopenia and prognosis of systemic treatment was explored.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Liver Cancer Sarcopenia

Interventions

gait speed; ct scan; grip strength and chair stand testDIAGNOSTIC_TEST

The chair stand test was administered, and the time required for the patient to stand five times from a sitting position without using the arms was measured. CT scan was to scan the patient's third lumbar level. For the gait speed test, the time that patients spent walking 8 meters on a flat indoor floor at usual walking speed was measured.Grip strength test:the dominant hand and the nondominant hand were measured twice intermittently (kg), and the average value of 4 values was obtained.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with clinical diagnosis of liver cancer * No cancer other than liver cancer has been diagnosed * Age ≥18 years Exclusion Criteria: * Patients who could not complete the standard tests and questionnaires * Patients received other therapies * Patients who had other causes of muscle weakness (injury, fracture, stroke, etc.) * Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)

Locations (1)

Gang Chen

Wenzhou, Zhejiang, China

Outcomes

Primary Outcomes

Short-term results

Post-treatment complications

Time frame: 3 months

Long-term results

Overall survival; Progression free survival

Time frame: 2 years

Data from ClinicalTrials.gov

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