A Prospective, Single-arm Clinical Study of Pabrolizumab in Combination With Cisplatin + 5-FU for the Neoadjuvant Treatment of Unresectable, Advanced Squamous Carcinoma of the Temporal Bone Single-arm Clinical Study

Inclusion Criteria: 1. Patients with advanced temporal bone carcinoma evaluated by an otolaryngologist as non-R0 resectable; CPS score \> 20. 2. Patients who had undergone surgery, chemotherapy, radiotherapy, etc. 3. Patients with T4 advanced temporal bone cancer, Patients with nasopharyngeal carcinoma after radiotherapy 4. Hematology, biochemistry, and organ function: * Hemoglobin ≥100 g/L (can be maintained or exceeded by transfusion); * Neutrophil absolute count ≥2.0×109/L; * Platelet count ≥100×109/L; * Total bilirubin ≤1.5 times the upper limit of normal; * Alt and ASPARTate aminotransferase ≤2.5 times the upper limit of normal value; * Creatinine ≤1.25 times the upper limit of normal; The creatinine clearance rate was ≥60mL/min. * Women of childbearing age (18-49 years) must exclude pregnancy. 5. General admission criteria: * Obtain informed consent signed by the patient or his legal representative; * Good patient compliance; * Medications can be taken orally; * Male or female aged ≥18 years and \< 75 years; * ECOG behavior status score 0-1, life expectancy \> 12 weeks; * Both men and women of reproductive age agreed to use a reliable method of contraception before entering the trial, during the study, and up to 8 weeks after stopping the drug. Exclusion Criteria: Patients who had cancer other than temporal bone cancer during the five years before the initiation of treatment in this study were excluded from: fully cured with surgery and disease-free survival of at least 5 years; carcinoma in situ of the cervix; cured basal cell carcinoma; bladder epithelial neoplasms (including Ta and Tis); * Known allergy to carboplatin, 5-FU, or any of the ingredients in this product; * Confirmed or suspected active immune disease. The following conditions can be included: the absence of a specific external stimulus will not develop; Systemic treatment is not required. * systemic use of steroid hormones (\> 10mg/ day equivalent of prednisone) or immunosuppressants within 14 days before first administration. Aerosolized inhalation or topical administration of steroid steroids may be used in the absence of active immune disease. * Previous interstitial lung disease, drug-induced interstitial disease, radiation pneumonia requiring hormone therapy, or any clinically proven active interstitial lung disease; * Any unstable systemic disease, including: Active infection, uncontrolled hypertension, unstable angina, the onset of angina within the last 3 months, congestive heart failure (≥ New York Heart Association \[NYHA\] Class II), myocardial infarction (6 months before enrollment), severe arrhythmia requiring medication, liver, kidney, or metabolic disease; * Known human immunodeficiency virus (HIV) infection, active hepatitis B or C; * Patients with mixed small cell lung cancer components; * Pregnant or lactating women; * A clear history of neurological or psychiatric disorders, including epilepsy or dementia; * Conditions deemed unsuitable for inclusion by other researchers.