The present study aimes at comparing the transradial and transfemoral approaches for partial splenic embolization in patients with hypersplenism.
Since its development in 1979, partial splenic embolization (PSE) has been universally accepted to treat patients with hypersplenism in preference to surgical splenectomy. The spleen is the primary source of antibodies, lymphocyte production, and responsible for phagocytosis of white cells. Additionally, it plays an essential role in the immune system. Unlike splenectomy, partial splenic embolization (PSE) maintained partial splenic function and was thought to be an effective alternative to treat thrombocytopenia and leukopenia resulted from hypersplenism with fewer complications. PSE is usually performed using a femoral artery approach that requires bed rest for a few hours. Recently, the transradial approach, with less obvious need for bed rest, has been more widely applied for cardiovascular intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
112
embolization of the splenic artery for the treatment of hypersplenism
Faculty of medicine, Zagazig university
Zagazig, Egypt
Technical Success of the Procedure
The achievement of a single puncture allowing access to splenic artery without periprocedural complications.
Time frame: Immediately after the procedure is complete
Average number of punctures
Number of arterial punctures required to complete the procedure
Time frame: Immediately after the procedure is complete
Procedural time
The time interval from starting the anaethesia till completion of the procedure
Time frame: Immediately after the procedure is complete
X-ray exposure duration
Duration of flouroscopy exposure during the procedure
Time frame: Immediately after the procedure is complete
Length of hospital stay
Number of days that the patient will spend in the hospital after the procedure.
Time frame: 7 days
Complications at access site
Access site adverse events such as vessel thrombosis, pseudoaneurysm or bleeding.
Time frame: 30 days
Procedural complications
Adverse events related to the procedure itself like splenic abscess, ascitis or portal vein thrombosis
Time frame: 30 days
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