CLIC1 in Patients Presenting PD

Seoul National University Bundang Hospital62 enrolled

Overview

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hip Fractures Hip Disease

Interventions

Perioperative deliriumBEHAVIORAL

Perioperative delirium

Hip surgeryPROCEDURE

Orthopedic hip joint surgery under spinal anesthesia

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia Exclusion Criteria: * Patients who are unconscious * Patients who are unable to communicate * Alzheimer * Parkinson Disease * Conversion to general anesthesia

Locations (1)

Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

expression pattern of CLIC1 protein

Time frame: Immediate after spinal anesthesia

Data from ClinicalTrials.gov

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