The Biomimetic Stent and Vascular Functions Study

Inclusion Criteria: * Peripheral artery disease * Target lesions in the proximal (3 cm distal to the CFA-bifurcation) middle and distal SFA * Clinical diagnosis of chronic, symptomatic lower limb ischemia as defined by Rutherford 2,3,4 * Planed peripheral intervention TASC A-D * Subject must be between 18 and 85 years old * Female of childbearing potential must have a negative pregnancy test within 10 days prior to index procedure and utilize reliable birth control until completion of the 12 month angiographic evaluation * Vessel diameter \>/= 4.0 mm and \</=7.0 mm * Target lesion length \< 140 mm (segment to be stented) * Willing to comply with the specified follow-up evaluation * Written informed consent prior to any study procedures * Pretreatment with an adequately sized ballon (1:1 ration to nonstenotic vessel diameter) * usage of Biomimics stent as described in the IFU, especially regarding stent diameters and vessel size Exclusion Criteria: * Bifurcational lesions of the CFA and lesions including the first 3 cm of the SFA, due to technical aspects of FMD measurement * Requiring stent implantation in the PA * Instent-Restenosis * Thrombolysis within 72 Hours prior to the index procedure * Aneurysm formations in the femoral artery or popliteal artery * Concomitant hepatic insufficiency, deep venous thrombus, coagulation disorder or receiving immunosuppressant therapy * Unstable angina pectoris at the time of the enrollment * Recent myocardial infarction or stroke \<30 days prior to the index procedure * Life expectancy less than 12 months * Septicaemia at the time of enrollment * Known or suspected active infection at the time of the index procedure, excluding an infection of a lower extremity wound of the target limb * Known or suspected allergies or contraindications to aspirin, clopidogrel or heparin * Presence of other hemodynamically significant outflow lesions in the target limb requiring a planned surgical intervention or endovascular procedure within 30 days after the index procedure