The investigators intend to compare Epstein-Barr virus antibody and Epstein-Barr virus DNA screening efficacy in first-degree relatives of nasopharyngeal carcinoma patients.
The investigators intend to test Epstein-Barr virus antibodies (Viral Capsid Antigen-immunoglobulin A， Epstein-Barr nuclear antigen 1-immunoglobulin A， early antigen-immunoglobulin A， Zta-immunoglobulin A， Rta-immunoglobulin G, Bnlf 2b) by ELISA and Epstein-Barr virus DNA by quantitative polymerase chain reaction, target sequencing and CRISPR-associated protein 12a in nasopharyngeal brushing and plasma of the same population at high-risk of nasopharyngeal carcinoma so as to determine the best method in nasopharyngeal carcinoma screening.
Study Type
OBSERVATIONAL
Enrollment
11,625
ELISA test of VCA-IgA，EBNA1-IgA，EA-IgA， Zta-IgA ，Rta-IgG and BNLF 2b in nasopharyngeal brushing and plasma
quantitative polymerase chain reaction, CRISPR-associated protein 12a and target sequencing of EBV DNA in nasopharyngeal brushing and plasma
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
RECRUITINGpositive predictive value
the ratio of subjects truly diagnosed as nasopharyngeal carcinoma to all those who had positive test results
Time frame: 3 years
negative predictive value
the ratio of subjects truly diagnosed as negative (do not have nasopharyngeal carcinoma) to all those who had negative test results
Time frame: 3 years
sensitivity
the percentage of subjects who test positive to those who have nasopharyngeal carcinoma
Time frame: 3 years
specificity
the percentage of subjects who test negative to those who do not have nasopharyngeal carcinoma
Time frame: 3 years
early diagnose rate
the ratio of patients with stage I and stage II disease to all those who have nasopharyngeal carcinoma
Time frame: 3 years
cost-effectiveness
the cost of detecting one nasopharyngeal carcinoma case
Time frame: 3 years
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