Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation

Seoul National University Hospital104 enrolled

Overview

The purpose of this study is to compare the sedation efficacy of dexmedetomidine and remimazolam for intraoperative sedation during regional block.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

104

Conditions

Orthopedic Disorder

Interventions

RemimazolamDRUG

0.075 mg/kg Remimazolam bolus infusion for 1 min, then 0.5\~1.0 mg/kg/h continuous infusion

DexmedetomidineDRUG

1 mcg/kg Dexmedetomidine infusion for 10 min, then 0.2\~0.7 mcg/kg/h continuous infusion

Eligibility

Sex: ALLMin age: 19 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient scheduled for lower extremity surgery under regional anesthesia, aged 19-70, of ASA class I or II. Exclusion Criteria: * Patient refusal * Contraindications to regional or neuraxial anesthesia (patient refusal, increased intracranial pressure, infection at puncture site, underlying neurologic disease, severe hypovolemia, aortic or mitral stenosis, thrombocytopenia or coagulopathy) * Contraindications to dexmedetomidine or remimazolam administration * Allergy to dexmedetomidine or remimazolam * Baseline MOAA/S score of 4 or less * Pregnancy * Other conditions considered unsuitable by the investigators

Locations (1)

Seoul National University Hospital

Seoul, Jongno-gu, South Korea