This study will investigate the epidemiology, risk factors, diagnostics, treatment, and the long-term prognosis of cerebral venous thrombosis in China.
The epidemiology, risk factors, diagnosis and treatment of Cerebral Venous Thrombosis (CVT) in China are still unclear. A retrospective hospital-based study will be conducted at fifty different hospitals across 31 provinces in China. This study will use ICD-10 to search patients diagnosed with CVT between January 1, 2018 and June 15, 2022 across 31 provinces and municipalities of 104 hospitals in China. Risk factors, clinical and radiological findings, treatment and short-term outcomes will be recorded from the hospital record system. Finally, a prospective follow-up will be conducted for all of the patients enrolled above. By combining data collected from retrospective hospital records with the new follow-up, it will be possible to better understand the epidemiology, risk factors, diagnosis, treatment and the long-term prognosis of CVT in China.
Study Type
OBSERVATIONAL
Enrollment
3,276
Xuan Wu Hospital,Capital Medical University
Beijing, Beijing Municipality, China
Favorable clinical outcome (modified Rankin score 0-1)
Time frame: Baseline to three years
All-cause mortality
A combination of death form of all causes
Time frame: Baseline to three years
Recurrence of cerebral venous thrombosis
Diagnosed by DSA, MRV, CTV or HR-MRI
Time frame: Baseline to three years
Favorable clinical outcome (modified Rankin score 0-2)
Time frame: Baseline to three years
Headache after CVT
Headache Impact Test - 6 score
Time frame: Baseline to three years
Incidence of hemorrhagic complication
Extracranial hemorrhage (fall in hemoglobin of 2 gram/dl or more within 48 hours) or intracranial hemorrhage
Time frame: Baseline to three years
Recanalization rate of cerebral venous system
Time frame: Baseline to three years
Incidence of epilepsy
Time frame: Baseline to three years
Incidence of acute ischemic stroke
Time frame: Baseline to three years
Incidence of pulmonary embolism
Time frame: Baseline to three years
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Psychological distress after CVT
Population Health Questionnaire (PHQ)-9 score
Time frame: Baseline to three years