Evaluation of D-chiro-inositol Treatments

Inclusion Criteria: * Good state of health; * Regular menstrual cycle. Exclusion Criteria: * pregnancy; * delivery in the previous 6 months; * currently breastfeeding; * menopause; * alcohol or drug abuse; * insulin resistance defined as HOMA-IR index greater than or equal to 2.5; * other medical morbidities, such as hypertension, PCOS, or diabetes; * oligomenorrhea or amenorrhea; * current treatment with corticosteroids or hormones (oral contraceptives, estrogensic, progestogensin); * use of GnRH analogues, SERMs, or SPRMs within the previous 6 months.