Safety and Biologic Impact (Pharmacodynamics) of Repeated Injections and Increasing Amounts of UPB-101 in Asthmatics

Inclusion Criteria: 1. Male or female, aged 18 to 60, and has physician-diagnosed asthma 2. Body mass index (BMI) between 18 and 35 kg/m2 3. Blood eosinophil cell count ≥200 (OR ≥150 combined with fractional exhaled nitric oxide \[a measure of lung airway inflammation\] \>25) at one screening visit and ≥150 at the other screening 4. Agrees to follow the required contraceptive techniques 5. Female or male participant agrees not to donate eggs or sperm, respectively, for a period of 120 days after the last dose of the study drug 6. Able to perform spirometry (breathing tests) 7. Asthma and non-biologic asthma medication have been stable for the past 2 months Exclusion Criteria: 1. Employee, consultant, and/or immediate family member of any person involved in the conduct of the study 2. Previous exposure to the study drug or known allergy/sensitivity to any of its ingredients 3. Pregnant or breastfeeding female 4. Unable to fast and avoid strenuous exercise for 9 hours prior to each site visit 5. Serious allergic reaction to any injected drug 6. Significantly abnormal clinical laboratory test results or a significant medical condition 7. Recently donated blood (including blood products) or experienced significant loss of blood 8. Has pacemaker or a significantly abnormal electrocardiogram 9. An active or a serious infection in the past 8 weeks 10. Poorly-controlled diabetes or abnormal kidney function 11. Tests positive to illicit drugs or nicotine and cannot limit alcohol consumption 12. Tests positive for human immunodeficiency virus antibodies (HIV), hepatitis B, hepatitis C antibodies, or tuberculosis 13. Received any vaccine within the past month 14. Received any immunosuppressant therapies in the past 15. Received an antibody or therapeutic biologic product in the last 6 months 16. Received steroids (other than inhaled) in the past 2 months 17. Participated recently in a clinical study 18. Current tobacco smokers or has smoked within the last year 19. Tested positive for COVID-19 in the past month