Prone Fluid Responsiveness in Children

Seoul National University Hospital40 enrolled

Overview

In pediatric patients in the prone position, the reliability of pulse pressure variation and stroke volume variation, and pleth variability index to predict fluid responsiveness have not previously been established. Perioperatively, in this setting, optimizing fluid management can be challenging, and fluid overload is associated with both intraoperative and postoperative complications. The investigator designed this study to assess the sensitivity and specificity of baseline PPV, SVV, and PVI the tidal volume (VT) challenge (VTC) and in predicting fluid responsiveness during elective neurosurgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Pediatric ALL

Interventions

TVCPROCEDURE

Tidal volume challenge from 6ml/kg to 10ml/kg for 1 min.

Eligibility

Sex: ALLMin age: 1 MonthMax age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective neurosurgery and requiring prone positioning Exclusion Criteria: * (1) chronic cardiac arrhythmia; (2) depressed left (\<30% of ejection fraction) (3) patients with pulmonary disease

Locations (1)

Hee-Soo Kim

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

fluid responsiveness prediction using AUC of ROC curve analysis

stroke volume index increase more than 10% from baseline after volume administration (10ml/kg) Fluid responsiveness parameters; PPV, SVV, PVI, rPVI before and after tidal volume challenge

Time frame: from induction of anesthesia to end of operation, about 5 hours

Data from ClinicalTrials.gov

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