Several studies agree on the increase in suicide attempts in children over the past 15 years. This trend has been aggravated by the COVID 19 pandemic. It is recognized that suicide attempts are mostly encountered in individuals with a psychiatric disorder. Serious suicide attempts, which probably better reflect the risk of completed suicide, are very poorly known and have been very little explored. They could be related to more specific and earlier psychiatric disorders or even concern children with developmental particularities that are insufficiently defined to fall under a categorical diagnosis, but which could be better understood with dimensional measurements. Better characterizing them would seem quite important given their high lethality. Indeed, a high lethality is found for half of the suicide attempts in children fewer than 12, contrasting with a moderate or low intentionality ; in children, the means used are often more violent and more lethal than in adolescents (over 12 years old): hanging, firearm, etc. The Necker-Enfants Malades hospital has a pediatric neurosurgery department as well as a specialized multidisciplinary team to care for polytraumatized children in a regional "Trauma Center" type structure. As a result, most children and adolescents in Ile-de-France who have made a violent suicide attempt are sent to the Necker hospital. Once medico-surgically stabilized, these children and adolescents are assessed by the hospital's child psychiatry team. This regional recruitment makes it possible to have an epidemiological representativeness. From this population, the investigative team proposes to better characterize the developmental profile and psychiatric disorders of children who have made a serious suicide attempt. The study also proposes to examine in detail the psycho-emotional development as well as the psychopathological characteristics of these children in order to shed light on these early and lethal acting out. The investigative team proposes in particular to use dimensional evaluations to analyze behavioral traits in more detail. To the knowledge of the child psychiatry department of the Necker Enfants Malades hospital, there is no such study to date. In addition to the question of neurodevelopmental disorders, an ancillary study will make it possible to question attachment disorders in children who have made a serious suicide attempt. In fact, a link between attachment disorders and suicidal ideation or attempted suicide has been shown in the literature. Attachment disorders correspond to an early imbalance in the bond between a child and the primary caregiver, particularly before the age of 3. Attachment relationships that do not allow a solid bond between the young child and the person occupying the maternal function may not be pathological in themselves but would be risk factors for pathologies in adolescence and adulthood, and in particular a category of so-called disorganized attachment disorders in the occurrence of dissociative symptoms.
In 2016, the French national institute of statistics and economic studies (INSEE) indicates about the death of children aged 5 to 14 in France, that 4.2% of deaths at this age (n=26) are due to suicide, with a possible sub- assessment of suicide in this age group because a certain number of deaths are attributed to accidents. Several studies agree on the increase in suicide attempts in children over the past 15 years. This trend has been aggravated by the COVID 19 pandemic. Indeed, several recent studies have reported deterioration in the mental health of children and adolescents since the start of the pandemic and an increase in the rate of suicidal ideation and suicide attempts in 2020. Among the factors that could explain this increase, we can cite the phenomena of social distancing and isolation. It is recognized that suicide attempts are mostly encountered in individuals with a psychiatric disorder. Indeed, psychological autopsies indicate a prevalence of psychiatric disorders of more than 90% among people who died by suicide. Nevertheless, serious suicide attempts, which probably better reflect the risk of completed suicide, are very poorly known and have been very little explored. They could be related to more specific and earlier psychiatric disorders or even concern children with developmental particularities that are insufficiently defined to fall under a categorical diagnosis, but which could be better understood with dimensional measurements. Better characterizing them would seem quite important given their high lethality. Indeed, a high lethality is found for half of the suicide attempts in children fewer than 12, contrasting with a moderate or low intentionality ; in children, the means used are often more violent and more lethal than in adolescents (over 12 years old): hanging, firearm, etc. The Necker-Enfants Malades hospital has a pediatric neurosurgery department as well as a specialized multidisciplinary team to care for polytraumatized children in a regional "Trauma Center" type structure. As a result, most children and adolescents in Ile-de-France who have made a violent suicide attempt are sent to the Necker hospital. Once medico-surgically stabilized, these children and adolescents are assessed by the hospital's child psychiatry team. This regional recruitment makes it possible to have an epidemiological representativeness. From this population, the investigative team proposes to better characterize the developmental profile and psychiatric disorders of children who have made a serious suicide attempt. The study also proposes to examine in detail the psycho-emotional development as well as the psychopathological characteristics of these children in order to shed light on these early and lethal acting out. The investigative team proposes in particular to use dimensional evaluations to analyze behavioral traits in more detail. To the knowledge of the child psychiatry department of the Necker Enfants Malades hospital, there is no such study to date. In addition to the question of neurodevelopmental disorders, an ancillary study will make it possible to question attachment disorders in children who have made a serious suicide attempt. In fact, a link between attachment disorders and suicidal ideation or attempted suicide has been shown in the literature. Attachment disorders correspond to an early imbalance in the bond between a child and the primary caregiver, particularly before the age of 3. Attachment relationships that do not allow a solid bond between the young child and the person occupying the maternal function may not be pathological in themselves but would be risk factors for pathologies in adolescence and adulthood, and in particular a category of so-called disorganized attachment disorders in the occurrence of dissociative symptoms. The adolescent relationship scale questionnaire (ARSQ), to determine attachment style, will be offered to children and adolescents who have made serious suicide attempts who will participate in the study as well as to a control group of children and adolescents.
Study Type
OBSERVATIONAL
Enrollment
200
Questionnaires will be completed only once : * Neurodevelopment in children: Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version (K-SADS-PL-5), the Social Responsiveness Scale (SRS), The Children's Communication Checklist-2 (CCC-2), The Autism-Tics, ADHD and Other Comorbidities Inventory (A-TAC), CONNERS-3, Sensory Profile 2 (DUNN) * Psychopathological profile of the child by evaluating the presence of psychotic symptoms: K-SADS-PL-5, Prodromal Questionnaire (F PQ16) * Presence of mood and anxiety disorders: Child Depression Inventory (CDI), Revised Children's Manifest Anxiety Scale (RCMAS) * Presence of sleep disorders: Children's Sleep Habits Questionnaire (CSHQ). The K-SADS-PL-5 will only be completed by subjects who have attempted suicide after the start of the study; it requires a semi-structured interview of the child by a child psychiatrist and cannot be done remotely. The other scales will be completed by all included subjects.
Determination of attachment style : Adolescent Relationship Scale Questionnaire (ARSQ). The questionnaire will be completed only once.
Hôpital Necker-Enfants Malades
Paris, France
RECRUITINGDescription of the distribution of scores of the Autism-Tics, ADHD and Other Comorbidities Inventory (A-TAC) assessing neurodevelopment
A-TAC is a hetero-questionnaire of 96 "gate items" used for basic screening and identification of proxies to diagnoses, organized in different modules, and 163 additional items tapping into more specific symptoms including 72 items (4/module) addressing psychosocial dysfunction and subjective suffering associated with that particular problem area, the age at onset and whether the problems are present or in remission. 3 answers are possible/item (yes, scored 1; yes to some extent, 0,5; no, 0). For each module in which at least one item is answered in the affirmative, the parents tell about whether or not the endorsed symptoms had led to (1) dysfunction at school, among peers, or at home, and (2) suffering on the part of the child. A "problem load score" is calculated as the sum of these 2 items (from 0 to 2), with a theoretically defined cut-off for problems "significant" at ≥ 1, indicating that one of the problem questions is fully endorsed or that both are endorsed "to some extent".
Time frame: Day 0
Evaluation of neurodevelopment by a dimensional scale (K-SADS-PL-5)
Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version (K-SADS-PL-5) : Semi-structured diagnostic interview to assess mental disorders in children and adolescents (6-18 years). It includes a dimensional and categorical assessment of the symptoms of current and past episodes of psychopathology, in order to make one or more diagnoses according to the DSM-5 criteria. For each category related to DMS-5 diagnosis, there are 4 possible answers for the most severe past episode (0: no information; 1: no diagnosis; 2: likely diagnosis, 3: clear diagnosis) and 5 possible answers for the actual episode (0: no information; 1: no diagnosis; 2: likely diagnosis, 3: clear diagnosis; 4: in partial remission).
Time frame: Day 0
Evaluation of neurodevelopment by a dimensional scale (SRS)
Social Responsiveness Scale (SRS) : 65-item hetero-questionnaires for children and adolescents from 4 to 18 years old concerning social awareness, cognition, communication and motivation, repetitive behaviors and restricted interests. Each item on the scale inquires about an observed aspect of reciprocal social behaviour that is rated on a scale from "0" (never true) to "3" (almost always true).
Time frame: Day 0
Evaluation of neurodevelopment by a dimensional scale (CCC-2)
Children's Communication Checklist (CCC-2) : 70-item hetero-questionnaire for children and adolescents from 4 to 16 years old which evaluates the structure of language, pragmatic difficulties and non-linguistic aspects of autistic behaviors (social relations and centers of interest). It does not allow the diagnosis of autism spectrum disorder. It quantifies the strengths and weaknesses of children's communication from 0 ("less than once a week") to 3 ("every day").
Time frame: Day 0
Evaluation of neurodevelopment by a dimensional scale (CONNERS-3)
CONNERS-3 : 108-item hetero-questionnaire to assess the presence of symptoms of inattention, hyperactivity, impulsivity and other frequently associated disorders in children and adolescents aged 6 to 18. Symptoms are rated on a Likert scale with severity ratings from 0 (not at all/never) to 3 (very much/ very frequently).
Time frame: Day 0
Evaluation of neurodevelopment by a dimensional scale (DUNN)
Sensory Profile 2 (DUNN) : hetero-questionnaire of 86 items evaluating the behavioral reactions of the child in response to sensory stimuli as well as their repercussions on occupational performance in children and adolescents from 3 to 15 years old. There are 5 possible answers for each item (always, scored as 1; frequently, scored as 2; sometimes, scored as 3; rarely scored as 4; and never scored as 5).
Time frame: Day 0
Correlation between neurodevelopmental particularities and the age of suicide attempt
Study of the correlation between the presence of neurodevelopmental particularities assessed by the dimensional scales (K-SADS-PL-5, A-TAC, SRS, CCC-2, CONNERS-3, DUNN) and the age of suicide attempt.
Time frame: Day 0
Presence of psychotic symptoms
Description of scale scores to assess the presence of psychotic symptoms in children who have made a serious suicide attempt. Prodromal Questionnaire French Version (F PQ16) : self-administered 16-item questionnaire for individuals under 35 years of age assessing the presence of attenuated psychotic symptoms. The cut-off for a significant presence of psychotic symptoms is ≥ 4 of the 16 items.
Time frame: Day 0
Description of associated mood disorders in children who have made a serious suicide attempt
Child Depression Inventory (CDI) : Self-questionnaire of 27 items which measures the intensity of depression in children and adolescents from 7 to 17 years old. Each item is rated from 0 (normal behavior for age or absent) to 2 (severe). The addition of the items gives a total between 0 and 54. The higher the score, the more severe the depression symptomatology is. Revised Children's Manifest Anxiety Scale (RCMAS) : Self-administered 37-item questionnaire assessing the level and nature of anxiety in children and adolescents aged 9 to 19, not allowing diagnosis of the various anxiety disorders in children. The total anxiety score can range from 0 to 28. The cut-off point for pathological anxiety is more than two standard deviations around the mean (T\>70).
Time frame: Day 0
Description of sleep characteristics in children who have made a serious suicide attempt
Children's Sleep Habits Questionnaire (CSHQ): 33-items hetero-questionnaire to assess sleep habits in children aged 4 to 10, validated in adolescents up to 17 years old. There are 3 possible answers for each item (rarely, scored as 1; sometimes, scored as 2; and regularly scored as 3).
Time frame: Day 0
Description of the distribution of scores of the Adolescent Relationship Scale Questionnaire (ARSQ) assessing the style of attachment
Self-questionnaire of 17 items rated 1 = Not at all like me, at 5=Totally like me, allowing to distinguish the 4 different attachment styles (secure, preoccupied, ambivalent, disorganized). The results of patients who made a serious suicide attempt will be compared with those of patients who made non-serious suicide attempts.
Time frame: Day 0
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