Clinical Investigation to Assess Safety and Performance of Dermal Filler of Hyaluronic Acid

Inclusion Criteria: 1. Subject who had provided written informed consent form. 2. Adult male or female subjects between 45 and 70 years old. 3. Subject with moderate (2) or higher score in the Wrinkle Severity Rating Scale (WSRS) in the lower two thirds, and in at least one of the two sides of the face, assessed at baseline by the treating investigator. 4. Subject must be willing to abstain from any other facial invasive treatment (plastic surgery, implants, peelings) in the lower two thirds of the face during the clinical investigation period. Exclusion Criteria: 1. History of severe or multiple allergies, including allergy or hypersensitivity to injectable hyaluronic acid gel, lidocaine, anesthetics, or nerve-blocking agents or any of the components of product. 2. Any disease at baseline that results in changes of facial contour or facial edema. 3. Active skin disease or inflammation on or near the injection area at baseline that could interfere with the clinical investigation injections or assessments. 4. History of connective tissue diseases. 5. Soft tissue augmentation in the previous 6 months with bovine collagen, in the previous 12 months with porcine or human collagen, or in the previous 18 months with hyaluronic acid or hydroxyapatite. 6. Any aesthetic treatment/procedure on the face in the previous 6 months that may interfere with study injections and/or study assessments. 7. Subjects who have received permanent facial implants within the previous 36 months. 8. Presence of any condition, which in the opinion of the investigator, made the subject unable to complete the clinical investigation per protocol. 9. Subjects who are currently participating in another clinical investigation which may interfere with this clinical investigation. 10. Pregnant or nursing subjects, and subjects who plan pregnancy during the clinical investigation period. 11. Subjects undergoing restrictive nutritional regimens. 12. Subjects who practice facial impact sports, such as boxing, karate, taekwondo and other similar sports.