Vasopressor Requirements Depends on Sedation Strategy

Inclusion Criteria: * Multi vascular lesions of the coronary arteries according to coronary angiography; * Heart valve damage was confirmed by heart ultrasound, which is subject to surgical correction (aortic stenosis of III degree with a gradient on the aortic valve of more than 42 mmHg, aortic insufficiency III, mitral valve stenosis II-III, mitral regurgitation II-III) * Age of patients from 18-80 years; * Patient consent to participate in the study; * Women who have a negative pregnancy test and use effective contraception throughout the study and for 3 weeks after its completion, or women who are unable to have children (women who have undergone a hysterectomy (removal of the uterus) or tubal ligation, women with a clinical diagnosis of infertility) or are menopausal for more than 1 year (absence of menstruation for at least 12 months). Adequate methods of contraception include: surgical sterilization, double barrier method of contraception, local contraception; Exclusion Criteria: * Refusal to participate; * Hypersensitivity to propofol, dexmedetomidine; * Prolonged mechanical ventilation in case of surgical complications (bleeding, inadequate perfusion of the myocardium); * Occurred ischemic stroke; * History of the ischemic stroke; * History of the neurodegenerative diseases; * History of the mental disorders; * Use of neuroleptics, antidepressants for the last 5 years; * History of the cardiac surgery in the past; * Patients with chronic pulmonary disease (GOLD 3-4) * Patients with asthma (moderate or severe), * Participation in any other clinical trial; * Gastric or duodenal ulcer with risk of bleeding; * Chronic renal failure (ClCr less than 50 ml / h) * Acute renal failure that occurred during surgery (ClCr less than 50 ml / h, or a decrease in the rate of diuresis to 0.1 ml / h in the first 4 hours after surgery and does not respond to diuretic therapy) * Chronic hepatic insufficiency if there are laboratory signs of hypo coagulation without the use of anticoagulant therapy (INR\> 1.5) * If the patient has not stopped taking anticoagulants or antiplatelet agents in the preoperative period: warfarin 5 days before surgery, clopidogrel 5-7 days before surgery, xarelto / pradaxa 3 days before surgery), * History of the hematological disease; * Alcohol abuse in the anamnesis (3-4 times a week). * Condition after chemotherapy; * Pregnancy, lactation.