A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.
Study Type
OBSERVATIONAL
Enrollment
2,607
Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum
Formal right hemicolectomy including terminal ileum, cecum, and ascending colon
Cleveland Clinic Flroida
Weston, Florida, United States
Overall survival
Percent of patients who were alive at five years of follow-up
Time frame: 60 months
Positive resection margins
the rate of surgical margins infiltrated by malignancy
Time frame: Immediate postoperative
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