The Effect of Non Invasive Brain Stimulation on Impulsivity in Borderline Personality Disorder

Ciusss de L'Est de l'Île de Montréal13 enrolled

Overview

A pilot study to examine the effects of Non-Invasive Brain stimulation on impulsive behaviour in patients diagnosed with Borderline Personality Disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Borderline Personality Disorder

Interventions

NeuroConnDEVICE

A neurostimulation decivse that works be generating weak electric current via Electrodes. These electrodes placed on a specific cerebral location, where the defect assumed to be there) to modulate the neuronal activity. This neuronal modulation does not induce or fire action potential but it facilitate action potentials and cerebral interconnection as well corticolimbic connection)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria * Clinical Diagnosis of Borderline Personality Disorder (DSM-V) * Resident of Great Montreal * Ability to make decision * Clinical score is equal or more than 17 in Borderline Personality Disorder Severity Index (BPDSI) resident of greater Montreal Area, Exclusion Criteria: * material Metal in the brain * History of seizure or epilepsy * severe scalp irritation or eczema * recent scares, cut wounds, tattoo on the scalp * severe substance use disorder * clinical diagnosis of severe mood disorders o * Active psychotic episode * Pregnancy

Locations (1)

Centre Recherche_ Institut Univesitaire de Santé Mentale à Montréal

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

The effect of NIBS on impulsivity (UPPS- Behavioral Impulsive scale)

Patients with BPD will complete UPPS impulsive behavioral scale, a self reported questionnaire, before the first tDCS session and after they complete the 10 sessions of tDCS sessions. this questionnaire consists of 45 questions with 4 likert scale range for each question. The questionnaire is divided into 4 subscales: Urgency, lack of premeditation, lack of perseverance, sensation seeking.

Time frame: 2-week stimulation session

Secondary Outcomes

The effect of tDCS on BPD severity overall ( Borderline Personality Disorder Severity Index: BPDSI)

The BPD patients who attend the tDCS sessions and the short-term psychotherapy will be evaluated by one psychiatric with a semi-structured interview evaluation, Borderline Personality disorder Severity Index (BPDSI)

Time frame: 3 months

The Effect of tDCS on Risk taking ( an impulsive behavior dimension)

a computerized measure of risk taking behavior. Each participant will have a set of 30 balloons with temporary and permanent bank. The possibility of balloon explosion increased each time the participant inflate ( click on the balloon) while the amount of money increased by 0.5 euro with each inflation. the participant could more the earned money from inflation anytime before unexpected balloon explosion to the permanent bank. The total number of the pumps will determine the probability of risk taking behavior

Time frame: 2 weeks

the effect of tDCS on depressive symptoms in BPD (Montgomery-Asberg Depression Rating Scale (MADRS))

A self reported questionnaire that assess the depressive symptoms in the last 3 days. it consists of 9 questions with 3 likert score range ; each question examines different aspect of depression.

Time frame: 2 weeks

Data from ClinicalTrials.gov

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