Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery

Korea University Guro Hospital230 enrolled

Overview

The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative delirium, deep NMB is expected to reduce the postoperative delirium. This study was designed to determine whether the deep NMB lowered the incidence of delirium after lumbar surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

230

Conditions

Lumbar Spine Disease

Interventions

Rocuronium for deep NMBDRUG

Deep neuromuscular blockade will be maintained using continuous infusion of rocuronium.

Rocuronium for moderate NMBDRUG

Moderate neuromuscular blockade will be maintained using continuous infusion of rocuronium.

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 70 and more; * Scheduled for an elective lumbar spine surgery; * ASA physical status 1-3 Exclusion Criteria: * Diagnosed neuromuscular disorder; * Contraindications to the study drug, e. g. known allergy or hypersensitivity, hypotension, bradycardia, higher grade atrioventricular block; * Patient with pre-existing cognitive impairment or dementia

Locations (1)

Seok Kyeong Oh

Seoul, Gangnam-gu, South Korea

Outcomes

Primary Outcomes

Delirium by CAM-ICU

Occurrence of delirium assessed by CAM-ICU during the post-operative 5 days

Time frame: from just after surgery at the PACU to post-operative 5 days

Secondary Outcomes

Intramuscular pressure

Intramuscular pressure at the para-spinal muscles

Time frame: intraoperative

Peak inspiratory airway pressure

Peak inspiratory airway pressure (mmHg)

Time frame: intraoperative

Data from ClinicalTrials.gov

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