Effect of Remimazolam on Motor Evoked Potential

Korea University Guro Hospital20 enrolled

Overview

This study was planned to investigate the degree of effect of remimazolam on MEP compared to propofol when monitoring the motion-inducing potential (MEP).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Spine Disease

Interventions

PropofolDRUG

Anesthesia induction and maintenance with propofol 60 minutes later, change the maintenance drug to remimazolam

Remimazolam BesylateDRUG

Anesthesia induction and maintenance with remimazolam 60 minutes later, change the maintenance drug to propofol

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 20-70 * Scheduled for elective spine surgery requiring monitoring of evoked potential * ASA physical status 1-3 Exclusion Criteria: * BMI ≥ 40 * Uncontrolled DM (HbA1c ≥ 9%) * Contraindications to the study drug: known allergy or hypersensitivity * Use of rate responsive cardiac pacemaker with bioelectrical impedence * Diagnosed neuromuscular disorder * Pre-existing motor weakness

Locations (1)

Seok Kyeong Oh

Seoul, Gangnam-gu, South Korea

Outcomes

Primary Outcomes

Motor evoked potential (MEP), before cross-over

Amplitude and latency of MEP before cross-over

Time frame: Intraoperative, just after confirmation of neuromuscular recovery, for 30 minutes

MEP, after cross-over

Amplitude and latency of MEP after cross-over

Time frame: Intraoperative, 30 minutes after alteration of the maintenance drug, for 30 minutes

Secondary Outcomes

Bispectral index

Bispectral index during MEP data collection

Time frame: Intraoperative

Blood pressure

Blood pressure during MEP data collection

Time frame: Intraoperative

Heart rate

Heart rate during MEP data collection

Time frame: Intraoperative

Data from ClinicalTrials.gov

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