Biomarkers and Postoperative Delirium in Elderly Patients

Henan Provincial People's Hospital400 enrolled

Overview

This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method to predict whether patients will develop postoperative delirium and improve the prognosis of elderly patients with postoperative delirium. Reduce the probability of postoperative complications, improve the long-term survival rate of patients after surgery.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Postoperative Delirium

Interventions

postoperative deliriumBEHAVIORAL

Postoperative delirium (POD) occurs within 1 week after surgery in patients, with obvious time characteristics, mainly occurring within 1-3 days after surgery. Postoperative delirium has adverse effects on the short and long term prognosis of patients. Patients with delirium have an increased risk of postoperative complications, perioperative death, longer hospital stay and increased medical costs during hospitalization.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age≥65 2. Patients undergoing hip replacement under spinal anesthesia 3. ASA grade I\~III; 4. Voluntarily participate in this study, and informed consent was signed by the patients themselves and their families Exclusion Criteria: 1. Patients with multiple fractures and trauma 2. Patients with preoperative cognitive dysfunction determined by MMSE scale; 3. Severe impairment of hearing, visual and language system functions; 4. Not suitable for or unwilling to undergo subarachnoid anesthesia 5. Patients who refuse to participate or cannot cooperate.

Locations (1)

Henan People's Hospital

Zhengzhou, Henan, China

RECRUITING

Outcomes

Primary Outcomes

neuroinflammatory biomarkers

Whether there are changes in neuroinflammatory biomarkers(Ykl40(pg/mL), procalcitonin(ng/mL), IL-17A,IL-23,INF-γ(IU), Tau(pg/mL), amyloid beta(pg/mL),etc) in cerebrospinal fluid and plasma between delirium patients and non-delirium patients before and after operation.

Time frame: preoperative、24 hours after surgery、48 hours after surgery

Central Contacts

Zhaoyu Wen, Bachelor

CONTACT

0086-18860371522 76338445@qq.com

Data from ClinicalTrials.gov

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