Topical Cannabidiol Application and Skin Vascular Reactivity

Penn State University

Overview

Cannabidiol, or CBD, is an over-the-counter "nutraceutical" that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Conditions

Effect of Drug

Interventions

CannabidiolBIOLOGICAL

Urbal Activ Extra Strength CBD Body Strong Balm applied to region of forearm to be stimulated by iontophoresis machine

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women 18 years of age and older * English speaking * Non-obese class III, BMI ≤ 39.9 * Normal HbA1C of \<6.5% Exclusion Criteria: * Abnormal resting heart rate (\<60 or \>100 bpm) or BP (systolic \<100 or \>129 mmHg, diastolic \<60 or \>100 mmHg) values * Rash, skin disease, disorders of pigmentation * Known skin allergies * Diabetes * Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.) * Illegal drug use * Recent (within the last 30 days) CBD users either topical or oral * Allergy or hypersensitivity to investigational agents * Women who are pregnant or breastfeeding

Locations (1)

Noll Laboratory

University Park, Pennsylvania, United States

Outcomes

Primary Outcomes

Cutaneous Vascular Conductance

pulse units as measured by laser Doppler flowmetry

Time frame: ~5 hours

Data from ClinicalTrials.gov

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