Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp

* over the age of 17 * normal pubertal development * regular menstrual cycles * stable weight for previous three months * normal body mass index * blood pressure systolic BP \< 140 mm Hg, diastolic \< 90 mm Hg * normal hemoglobin * hemoglobin A1C \< 6.5% * BUN, creatinine not elevated * AST, ALT \< 3x upper limit of normal * negative serum pregnancy test Exclusion Criteria: * active illicit drug use, * history of a medication reaction requiring emergency medical care, * difficulty with blood draws. * history of hypertension, diabetes, heart disease, high cholesterol, cancer, or clotting disorders. * history of chronic disease that has required hospitalization * recent use of prescription medications which interfere with metabolism or reproduction (recent = within 5 half-lives of the drug) unless it is birth control * history of diabetes in a first degree relative * hyperlipidemia by fasting lipid panel