This study will investigate the impact of dietary protein intake on progressive muscle loss and functionality (sarcopenia) in older adults with type 2 diabetes mellitus. Sarcopenia is known to have a bidirectional interaction with type 2 diabetes mellitus. Therefore in order to address this bidirectional complication we suggest that an increased intake of dietary protein at 1.5 gr/kg/day (current official recommendation is 0.8 gr/kg/day) could help to treat the sarcopenia, which in turn will help to ameliorate the type 2 diabetes mellitus progression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
25
dietary plan having dietary protein of 1.5 gr/kg/day
dietary plan having dietary protein of 0.8 gr/kg/day
National and Kapodistrian University of Athens
Athens, Attica, Greece
skeletal muscle mass index
Change from baseline in skeletal muscle mass index and will be assessed by dual energy x-ray absorptiometry ((leg lean mass+arm lean mass)/height\^2)
Time frame: Week 0, week 12
calf circumference
Change from baseline in calf circumference and will be assessed by measuring tape
Time frame: Week 0, week 6, week 12
handgrip strength
Change from baseline in handgrip strength and will be assessed by handgrip dynamometer
Time frame: Week 0, week 6, week 12
Sit to stand test
Change from baseline in "Sit to stand" test which measures muscle functionality and will be assessed by chronometer
Time frame: Week 0, week 6, week 12
Timed up and go test
Change from baseline in "Timed up and go" test which measures muscle functionality and will be assessed by chronometer
Time frame: Week 0, week 6, week 12
10 meters walking test
Change from baseline in 10 meters walking test which measures muscle functionality and will be assessed by chronometer
Time frame: Week 0, week 6, week 12
blood glucose
Change from baseline in blood glucose and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Serum insulin
Change from baseline in serum insulin and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Glycosylated hemoglobin (HbA1)
Change from baseline in HbA1 and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
C reactive protein
Change from baseline in C reactive protein and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Dietary intake of macro- and micro-nutrients
Change from baseline in macro- and micro- nutrients and will be assessed with -3 day recall
Time frame: Week 0, week 3 , week 6, week 9, week 12
cholesterol level
Change from baseline in cholesterol level and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
triglycerides level
Change from baseline in triglycerides level and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
low-density lipoprotein (LDL)
Change from baseline in LDL and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
high-density lipoprotein (HDL)
Change from baseline in HDL and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Enzymatic activity of glutathione peroxidase in plasma
Change from baseline in enzymatic activity of glutathione peroxidase in plasma and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Enzymatic activity of glutathione peroxidase in red blood cell lysate
Change from baseline in enzymatic activity of glutathione peroxidase in red blood cell lysate and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Enzymatic activity of superoxide dismutase in plasma
Change from baseline in superoxide dismutase in plasma and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12
Enzymatic activity of superoxide dismutase in red blood cell lysate
Change from baseline in superoxide dismutase in red blood cell lysate and will be assessed by commercially available kit
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Time frame: Week 0, week 6, week 12
Protein carbonyls in plasma
Change from baseline in protein carbonyls in plasma and will be assessed by commercially available kit
Time frame: Week 0, week 6, week 12