TIBOLA (TIck-BOrne LymphAdenopathy) is a tick-borne disease. The pathogen is most often rickettsia (R. slovaca or R. raoultii), but other strict intracellular bacteria have been described (Francisella tularensis, Coxiella burnetii, Bartonella hensenlae). Transmitted by ticks (Dermacentor), it is characterized by an inoculation eschar at the tick bite site, accompanied by painful loco-regional lymphadenopathy. It is most often a benign pathology, which can nevertheless leave sequellar alopecia or persistent asthenia. In spring 2021, an impression of increased cases was reported by clinicians in Eastern France. The study aims to clarify the clinical-biological presentation and the evolution of the number of cases of TIBOLA in this region between 2016 and 2021. At the same time, entomologists have noted an upsurge in this tick in certain biotopes in recent years.
Study Type
OBSERVATIONAL
Enrollment
20
Yves Hansmann
Strasbourg, France
RECRUITINGElisabeth Baux
Vandœuvre-lès-Nancy, France
RECRUITINGNumber of cases of TIBOLA
Time frame: baseline
Epidemiological and demographic characteristics
gender, age, habitat, hobbies, occupation
Time frame: baseline
Characteristics of tick bites
frequency, location, date
Time frame: baseline
Frequency of the various symptoms and clinical signs of the disease
inoculation ulcer, alopecia, lymphadenopathy, asthenia, fever, rash, headache, arthromyalgia, pruritus, facial oedema, other
Time frame: baseline
Biological results
serology and PCR of rickettsia, non-specific abnormalities
Time frame: baseline
Treatment
nature, efficiency
Time frame: baseline
Entomological analysis
respective proportion of Dermacentor and Ixodes encountered on the territory. Detection by molecular biology of the presence of Rickettsia spp. in ticks
Time frame: evolution between 2016 and 2021
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