Renal Considerations in the Heat Stress Recommendations (Aim2)

Indiana University18 enrolled

Overview

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration that elicit oxidative stress and inflammation in the renal tubules. The purpose of this study is to determine whether hydration status modifies the development of renal oxidative stress and inflammation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Hot Weather; Adverse Effect Kidney Dysfunction Kidney Injury Hyperthermia Dehydration

Interventions

Fluid replacementPROCEDURE

Participants will drink Gatorade Zero ad libitum, up to 1 cup every 15 minutes.

No fluid replacementPROCEDURE

Participants will not be permitted to drink.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 44 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women * 18-44 y old * Body mass index ≤35.0 kg/m2 * Self-reported to be healthy Exclusion Criteria: * Not within defined age range * Estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2 * Body mass index \>35.0 kg/m2 * Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery * Hypertension during screening (systolic blood pressure \>139 or diastolic blood pressure \>89) * Using medications that blunt the physiological response to exercise (e.g., beta blockers) * Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics) * Positive pregnancy test at any time during the study or breast feeding * Current tobacco or electronic cigarette use or consistent use within the last 2 years * Answered "Yes" to any question on Page 1 of the PAR-Q+.