The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly patients and recommend optimized dosage regimens.
Study Type
OBSERVATIONAL
Enrollment
500
phenytoin, carbamazepine, lamotrigine, levetiracetam, perampanel, etc. as part of routine treatment.
Wei Zhao
Jinan, Shandong, China
RECRUITINGThe peak plasma drug concentration of antiepileptic drugs.
To detect the peak plasma drug concentration of antiepileptic drugs.
Time frame: at (0-4) h after oral administration
The random plasma drug concentration of antiepileptic drugs.
To detect the random plasma drug concentration of antiepileptic drugs.
Time frame: at (4-10) h after oral administration
The trough plasma drug concentration of antiepileptic drugs.
To detect the trough plasma drug concentration of antiepileptic drugs.
Time frame: at (1-2) h before the next administration
The incidence of adverse drug reaction
Time frame: Through study completion, an average of 14 days
The frequency of seizures
Time frame: Through study completion, an average of 14 days
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