Multicenter Clinical Study on the Optimal Treatment Protocol and Outcome of Cough Variant Asthma With Chinese and Western Medicine

change from baseline in Cough-related Symptom Scale

This scale consists of two parts. Question1-5 come from Chinese national guideline on diagnosis and management of cough (2021) to evaluate the symptom of cough. Question6-10 are some accompanying performances, including cough-stimulated factors like wind, cold air, smoking etc, sputum, sensations of "persistent tickling", "thirsty", "Qi inversion" in throat.

Time frame: baseline and week 8 ,baseline and week 32

change from baseline in Cough severity visual analogue scale

Cough severity visual analogue scale (VAS) is used to record participants' assessments of cough severity. It is shown as a 0-mm to 100-mm liner scale ranging from "no cough" to "severe cough". The bigger score represents more severe cough.

Time frame: baseline and week 8 ,baseline and week 32

change from baseline in Leicester Cough Questionnaire

Leicester Cough Questionnaire, as a useful tool in clinical trial, consists of 19 items which is a repeatable, valid self-evaluated quality of life measure of chronic cough and responsive to change .

Time frame: baseline and week 8 ,baseline and week 32

change from baseline in Pulmonary function

Pulmonary function test reveals some details of a patient's condition in respiratory function, like forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, peak expiratory flow (PEF), forced expiratory flow 25% (FEF25), forced expiratory flow 75% (FEF75), forced expiratory flow between 25% and 75% of forced vital capacity (FEF(25-75)) etc.

Time frame: baseline and week 8 ,baseline and week 32

CVA recurrence rate from week 8 to week 32

CVA recurrence rate is defined as the occurance rate of similar cough which conforms to CVA diagnosis criteria during 6-month observation.

Time frame: week 32

the ratio of progressing to typical asthma from week 8 to week 32

the ratio of progressing to typical asthma is characterized as the ratio of participants who turning from CVA into classic asthma based on Guidelines for bronchial asthma prevent and management (2020 edition) during 6-month observation.

Time frame: week 32

change from baseline in fractional exhaled nitric oxide

Nitric oxide (NO) is produced by inducible nitric oxide synthase (iNOS) in airway epithelial cells and FENO is associated with eosinophilic airway inflammation which usually indicates the sensitivity to ICS.

Time frame: baseline and week 8 ,baseline and week 32

change from baseline in Serum IgE

IgE is linked to its ability to affect several immune and structural cells involved in allergic asthma.

Time frame: baseline and week 8 ,baseline and week 32