Low Fresh Gas Flow in Prone Position

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization46 enrolled

Overview

Low flow anesthesia in the prone position was safe in terms of systemic hemodynamics and did not reduce cerebral oxygenation compared to normal flow.

Patients were randomly allocated to either low fresh gas flow(LF, 0,5 L/min during maintenance) or normal flow (NF, 2 L/min)) general anesthesia. In both groups, participants were first administered with 100% oxygen at a 4 L/min flow rate. Propofol 2-2,5 mg/kg, rocuronium bromide 0,6 mg/kg, and fentanyl 1 mcg/kg IV were used for anesthesia induction.In the operating room, pulse rate, mean arterial pressure (MAP), peripheral hemoglobin oxygen saturation (spO2), and right and left side regional cerebral oxygen saturation (Masimo's O3 regional oximetry device) were measured before premedication and anesthesia induction, at 10 minutes after endotracheal intubation, at 10 minutes after prone positioning, at 1st, 2nd, 3rd, 4th and 5th hours of operation, before repositioning to supine, after the resumption of supine position and at 5 minutes after extubation. In conclusion, low flow anesthesia in patients undergoing surgery in the prone position did not cause a reduction in cerebral oxygenation compared to normal flow.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Anesthesia

Interventions

Low Fresh Gas Flow in Prone PositionPROCEDURE

In the low fresh gas flow group, the flow rate was reduced to 0.5 L/min

Normal Fresh Gas Flow in Prone PositionPROCEDURE

In the normal flow rate group, the gas flow rate was reduced to 2 L/min during the maintenance phase.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * undergoing surgery in the prone position * having an American Society of Anesthesiologists (ASA) physical status I to III * willingness to participate in the study Exclusion Criteria: * having a Glasgow coma scale (GSC) score ≤ 12 * previous history of cranial surgery * advanced cardiovascular and/or pulmonary disease * mental retardation * neurological disease

Locations (1)

Prof. Dr. Cemil Tascioglu City Hospital

Istanbul, Sisli, Turkey (Türkiye)

Outcomes

Primary Outcomes

Low and Normal Fresh Gas Flow Difference in Prone Position

Whether low flow anesthesia in the prone position is safe in terms of systemic hemodynamics and cerebral oxygenation compared to normal flow anesthesia

Time frame: Systemic and cerebral oxygenation values were measured 10 minutes after induction to general anesthesia and followed up to 10 minutes were left to completion of the surgery for about 5 hours, which may vary according to the duration of the surgery.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.