A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of RO7303509 in Participants With Systemic Sclerosis

Inclusion Criteria: Inclusion Criteria for the MAD Stage: * Weight of 45-150 kg at screening * Diagnosis of SSc, as defined by 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria and ≤ 10 years disease duration from first non-Raynaud's symptom * Agreement to remain abstinent or use an effective contraceptive method among males and females with childbearing potential for 4 months after last dose of study drug Inclusion Criteria for the OSE Stage: * No clinically significant change in eligibility status * Completion of the MAD and ability to roll over into the OSE within 5 days Exclusion Criteria: * Active rheumatic autoimmune disease other than SSc requiring treatment with disease-modifying therapy * Pulmonary disease with forced vital capacity (FVC) ≤ 50% of predicted * History or clinical manifestations of significant metabolic, hepatic, renal, pulmonary, cardiovascular, hematologic, gastrointestinal, urologic, neurologic, or psychiatric disorders * History of severe allergic or anaphylactic reactions to human, humanized, or murine monoclonal antibodies * Pregnant or breastfeeding, or intending to become pregnant during the study or within 4 months after the final dose of study drug * Major surgery within 8 weeks prior to screening, or major planned surgery during the study or within 3 months after the final dose * Positive hepatitis C virus (HCV) antibody, hepatitis B surface antigen (HBsAg), or human immunodeficiency virus (HIV) antibody test at screening * Any serious medical condition or abnormality in clinical laboratory tests