Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

Johns Hopkins University

Overview

Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance. It is especially severe and highly prevalent in high altitude residents. Intervening on nocturnal hypoxemia may therefore improve glucose control and decrease the public health burden in high altitude populations. The objective of this study is to examine the impact of hypoxemia on glucose homeostasis in high altitude residents. The investigators will address this objective by examining the effect of supplemental oxygen on glucose in a randomized cross-over study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Sleep-Disordered Breathing Glucose Intolerance

Interventions

Compressed AirOTHER

Participants will be instructed to use compressed air during sleep as a placebo control.

Supplemental OxygenOTHER

Participants will be instructed to use supplemental oxygen at rate of 2lpm during sleep.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Permanent residents of Puno, Peru Exclusion Criteria: * Recent travel to low altitude (\<3000 m) * Oxygen use * Pregnancy * Morbid obesity (BMI \> 40 kg/m2) * Current smoking * Diabetes * Other sleep disorders (e.g. circadian rhythm disorder or insomnia) * Use of open fires in the home (i.e. for cooking or heat) * Chronic Mountain Sickness (CMS) as defined by a daytime oxyhemoglobin saturation \< 85%, Qinghai CMS \>10 or excessive erythrocytosis as defined by hemoglobin \>19 g/dL in women or \>21 g/dL in men.