Multicenter Observational Study of PSC and IgG4-SC in China

Inclusion Criteria: * Age above 18 years old, * Male or Female, * Patients admitted in our medical centers which met the PSC criteria according to The European Association for the Study of the Liver Clinical Practice Guidelines "Management of cholestatic liver diseases" in 2009; or patients diagnosed with IgG4-SC which met initially using the Japan Pancreas Society criteria and confirmed using HISORt criteria. Exclusion Criteria: * Female subjects who is pregnant, breastfeeding or is considering being pregnant during the study; * History of other malignancies, including hematological tumors, solid tumors except hepatobiliary system; * History of infectious diseases, including hepatis A, B, C, E and tuberculosis.