The purpose of this study is to determine whether ASC42 alters the pharmacokinetics of atorvastatin in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
12
Atorvastatin followed by ASC42 daily followed by separate co-administration of atorvastatin
Atorvastatin followed by ASC42 daily followed by separate co-administration of atorvastatin
ICON
San Antonio, Texas, United States
Evaluate the pharmacokinetics (PK) of atorvastatin and its two metabolites by Peak Plasma Concentration (Cmax) in the presence or absence of ASC42
Time frame: 120 hours
Evaluate the pharmacokinetics (PK) of Atorvastatin and its two metabolites in the presence of ASC42 by Area under the curve from the time of dosing extrapolated to infinity (AUC(0-inf))
Time frame: 120 hours
Evaluate the pharmacokinetics (PK) of atorvastatin and its two metabolites by time to peak plasma concentration (Tmax) in the presence or absence of ASC42
Time frame: 120 hours
Safety and tolerability of Atorvastatin in the presence of ASC42 evaluated by incidence of treatment emergent adverse events (TEAEs)
Time frame: Baseline to Day 30
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.