Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions. Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.
For this study the investigators propose to include an additional CEST sequence in standard PET/MRI exam in order to obtain a cartography with biochemical informations from tissues in patients with glioma or brain metastases.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
800
CE-Marked Advanced Technology Software Modules (ATSM) for Magnetic Resonance Imaging from General Electric Healthcare
France Institut de cancérologie Strasbourg Europe
Strasbourg, France
RECRUITINGObtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases
Evaluation at the cerebral level on the acquisition images of residual volume in MRI
Time frame: through study completion, up to 14 years
Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases
Evaluation at the cerebral level on the acquisition images of tumoral metabolic activity in PET
Time frame: through study completion, up to 14 years
Correlate intratissular pH mapping and location of recurrence
Time frame: through study follow-up, up to 10 years
Correlate average pH of the tumor and histopathology
Time frame: through study follow-up, up to 10 years
Correlate average pH of the tumor and Disease-Free Survival (DFS)
Time frame: through study follow-up, up to 10 years
Correlate average pH of the tumor and Overall survival (OS)
Time frame: through study follow-up, up to 10 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.