In this study, patients with PD-L1 positive locally advanced patients with resectable gastric cancer or gastroesophageal junction adenocarcinoma were invited to participate in the study.To evaluate the efficacy and safety of patients with PD-L1 positive gastric cancer or gastroesophageal junction adenocarcinoma (≥T3 and the number of lymph node metastasis ≥1, and No distant metastasis) using Toripalimab combined with docetaxel, oxaliplatin, fluorouracil, leucovorin (FLOT regimen) .
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
FLOT: Docetaxel 50mg/m2 ivd d1 + oxaliplatin 85mg/m2 ivd d1 + leucovorin 200mg/m2 ivd d1 + 5-FU 2600mg/m2 civ, Q2W Toripalimab 3mg/kg, intravenously administered on the first day of each cycle, Q2W.
First Hospital of Jilin University
Changchun, Jilin, China
RECRUITINGPathological complete response (pCR)
Time frame: 3 months
event-free survival (EFS)
Time frame: 2 years
disease-free survival (DFS)
Time frame: 2 years
overall survival (OS)
Time frame: 2 years
objective response rate (ORR)
Time frame: 3 months
R0 Surgical conversion rate
Time frame: 3 months
major pathological response (MPR)
Time frame: 3 months
Incidence and severity of adverse events
Time frame: 6 months
index of tumor-infiltrating lymphocyte (sTIL) infiltration
Time frame: 3 months
type and number of intestinal flora
Time frame: 3 months
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