The Phase 2 study will be conducted in adult patients with confirmed Dengue infection and will investigate safety, PK, and pharmacodynamics (PD) in this population. The study will be conducted in several dosing cohorts to enable dose selection for subsequent trials
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
21
Atea Study Site
Belo Horizonte, Brazil
Change in Dengue (DENV) Viral Load From Baseline
To investigate the antiviral activity of AT-752 versus placebo in terms of reduction of DENV RNA from baseline in adult subjects with confirmed DENV infection
Time frame: Baseline, Day 2, Day 3, Day 4, Day 5, Day 6, Day 8, Day 14, Day 28
Pharmacokinetic (PK) Endpoint
Maximum plasma concentration (Cmax) of AT-281
Time frame: Day 3: 0, 0.5, 1, 2, 4, 6 hours post-dose
Pharmacokinetic (PK) Endpoint
Area under the concentration-time curve (AUCtau) of AT-281
Time frame: Day 3: 0, 0.5, 1, 2, 4, 6 hours post-dose
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Atea Study Site
Campo Grande, Brazil
Atea Study Site
Cuiabá, Brazil
Atea Study Site
Manaus, Brazil
Atea Study Site
Natal, Brazil
Atea Study Site
Porto Velho, Brazil
Atea Study Site
Recife, Brazil
Atea Study Site
Ribeirão Preto, Brazil
Atea Study Site
Rio de Janeiro, Brazil
Atea Study Site
São José do Rio Preto, Brazil
...and 22 more locations