A Study of MG-K10 in Subjects With Atopic Dermatitis

key Inclusion Criteria: 1. Aged 18 - 70 years (inclusive), male or female; 2. Patients diagnosed with AD according to American Academy of Dermatology Consensus Criteria (2014) for at least 6 months prior to screening and meet the following criteria: * EASI score ≥ 16 at the screening and baseline visits; * IGA score ≥ 3 at the screening and baseline visits; * AD affected body surface area (BSA) percent ≥10% at the screening and baseline visits; * Documented recent history (within 6 months before the screening) of inadequate response to treatment with potent topical corticosteroids for at least 4 weeks or super-potent topical corticosteroids for at least 2 weeks, or topical calcineurin inhibitors for 4 weeks, or prior systemic use of corticosteroids or immunosuppressive agents for more than 2 weeks; Key Exclusion Criteria: 1. Subjects currently diagnosed with other active skin disorders (e.g., psoriasis or lupus erythematosus) that may affect AD evaluation; 2. Subjects with concomitant diseases that may require systemic hormone therapy or other interventions or require active and frequent monitoring; 3. Subjects with unstable or not well controlled apparent cardiac, pulmonary, gastrointestinal, hepatic, renal, hematological, neurological and psychological diseases that is considered by the investigator to be clinically significant； 4. Patients with ocular diseases that are not suitable for enrollment by the investigator； 5. Use of biological agents within 12 weeks prior to randomization or within 5 half-lives (whichever is longer)； 6. Use of topical corticosteroids, topical calcineurin inhibitors, antibiotic compound cream and other topical products for AD treatment within 1 week prior to randomization; 7. chest X-ray or CT examination within 3 months prior to screening/during the screening period suggests the presence of active tuberculosis infection； 8. History of parasitic infection or travel to endemic areas (South America and Africa) half a year prior to screening。