Association Between Peripheral Muscle Function and Quality of Life in Obese Subjects

Overview

The assessment of health status and physical function is fundamental in patients with obesity, as they play an important role among the various factors influencing the quality of life in this population. Several studies have shown an association between high BMI values and a significant deterioration in quality of life, especially in women. Excess body fat in obese patients seems to be responsible for muscle atrophy. This causal link is probably related to dysfunctions in adipose tissue, leading to a decrease in the expression of proteins responsible for muscle contraction. The recent literature highlights an alteration in quality of life, particularly in obese and elderly subjects, for which changes in muscle function are partly responsible. Changes in muscle function can be assessed by simple, rapid and non-invasive tools. They could be used to identify obese subjects at risk of they could be used to identify obese subjects at risk of muscle atrophy, to stratify the risk, and to propose prophylactic intervention or early management. The main objective of this study is to evaluate the association between structural alteration of the quadriceps and quality of life in obese patients. The secondary objectives are to evaluate : * The association between quadriceps thickness and quality of life ; * The association between grip strength and quality of life ; * The association between quadriceps strength and quality of life ; * The association between quadriceps strength and ultrasound measurements of the quadriceps. This is a prospective, monocenter, observationnal and cohort study. All outpatients for nutrition assessment will be included.

1. Rationale 1.1 Obesity, a global public health Obesity is a disease of multifactorial origin, linked to nutritional alterations, genetic, psychological, socio-economic factors and more sedentary behaviour (4) (5). The prevalence of obesity continues to increase in all age groups and in all socio-economic groups. 1.2 Functional consequences of obesity. Patients with obesity with or without metabolic disorders have impaired health, including mental problems and reduced quality of life (12). In younger obese subjects the investigators also observe a decrease in quality of life compared to normal weight subjects, where muscle capacity may be a potential factor associated with impaired quality of life (13). 1.2.1 Peripheral muscle damage A decrease in the specific force of the muscle, a decrease in force in relation to the sectional area, is observed in subjects with obesity. There is therefore probably a structural alteration of the muscle in the obese patient, which has not yet been described in the literature (17). 1.3 Peripheral muscle ultrasound Muscle ultrasound measurements have become increasingly used as a non-invasive method of determining muscle characteristics (21). Muscle characteristics, particularly muscle size and quality, have been shown to be related to muscle strength and power as well as cardiovascular performance. 2. Research hypothesis The investigators hypothesise that impaired peripheral muscle function is associated with impaired quality of life in obese subjects. 3 Objective 3.1 Main objective The main objective of this study is to evaluate the association between structural alteration of the quadriceps and quality of life in obese patients. 3.2 Secondary objectives The secondary objectives are to evaluate : * The association between quadriceps thickness and quality of life ; * The association between grip strength and quality of life ; * The association between quadriceps strength and quality of life ; * The association between quadriceps strength and ultrasound measurements of the quadriceps. 4\. Type of study This is a prospective, monocenter, obversational cohort study. The research will be conducted in accordance with the protocol. 5\. The duration of recruitment will be 9 months. 6\. Standard assessment procedures: Hand Grip Force, Maximum Voluntary Force of the quadriceps. 7\. Assessment procedures added by the research: Muscle ultrasound and Quality of Life Scale. 8\. Statistical aspects: Statistics will be primarily descriptive and will be based on means (+/- standard deviation) or medians \[minimum-maximum\] depending on the distribution of quantitative variables. Qualitative variables will be described in terms of numbers and percentages. Univariate comparisons will use the usual statistical tests after verification of the distribution of the variables (Chi2 or Fisher's test, t-test, anova or their non-parametric equivalents Wilcoxon and Kruskal-Wallis tests). The risk of low quality of life in the presence of impaired muscle function will be described by the Odd-Ratios. Tests will be performed at the 5% significance level. The 95% confidence intervals will be provided for each estimate. 9\. Expected results in terms of scientific and professional advances: This study will evaluate the association between peripheral muscle function and quality of life impairment in obese patients hospitalized in HDJ Nutrition. The results of this study will help confirm the association of muscle status on quality of life in obese patients, which is not yet clearly established in the scientific literature. If appropriate, these results will make it possible to propose non-invasive and inexpensive predictive tools to screen for muscle damage in this patient population. This screening could make it possible to propose early management programmes, such as exercise re-training or the introduction of adapted physical activity. 10\. Expected benefits for the patient The use of non-invasive tests of muscle function could allow early identification of obese subjects whose impairment of muscle function could be associated with a poorer quality of life. This could allow us to propose an adapted therapeutic strategy, such as the implementation of an exercise training programme, adapted physical activity or therapeutic education.