The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.
Old Dominion University
Norfolk, Virginia, United States
RECRUITINGContinuous glucose monitoring
Time frame: 3 days before removal of exercise
Continuous glucose monitoring
Time frame: After removal of exercise for 5 days
Continuous glucose monitoring
Time frame: After return to exercise for 3 days
Flow mediated dilation
This measure assess blood vessel health non-invasively
Time frame: 3 days before removal of exercise
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
Time frame: After removal of exercise for 5 days
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
Time frame: After return to exercise for 3 days
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