The purpose of this study is to investigate glycaemic control and other clinical parameters in glucagon like peptide -1 (GLP-1) naive adult participants with type 2 diabetes (T2D) who initiated once weekly (OW) semaglutide in local clinical practice in North Macedonia. The participants were treated according to current clinical practice, applicable local labels, and standard of care as per physicians' discretion. The total duration of the study is planned to be approximately 30 weeks which is the period from OW semaglutide initiation to end of follow up.
Study Type
OBSERVATIONAL
Enrollment
314
Participants who initiated once weekly (OW) semaglutide in routine clinical practice in were enrolled in the study. The participants were treated according to current clinical practice, applicable local labels, and standard of care as per physicians' discretion.
Novo Nordisk Investigational Site
Bitola, North Macedonia
Novo Nordisk Investigational Site
Debar, North Macedonia
Novo Nordisk Investigational Site
General Hospital Kavadarci, North Macedonia
Novo Nordisk Investigational Site
Gostivar, North Macedonia
Novo Nordisk Investigational Site
Kičevo, North Macedonia
Novo Nordisk Investigational Site
Kočani, North Macedonia
Novo Nordisk Investigational Site
Kumanovo, North Macedonia
Novo Nordisk Investigational Site
Ohrid, North Macedonia
Novo Nordisk Investigational Site
Prilep, North Macedonia
Novo Nordisk Investigational Site
Shtip, North Macedonia
...and 7 more locations
Change in glycated haemoglobin (HbA1c)
Measured as percentage (%) point.
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in body weight
Measured in kilograms (kg).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in body weight
Measured as percentage (%).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in waist circumference
Measured in centimeter (cm).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in fasting plasma glucose (FPG)
Measured in millimoles per liter (mmol/l).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in Lipid parameters (total cholesterol, low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc], triglycerides)
Measured in millimoles per liter (mmol/L).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Change in Blood Pressure (systolic and diastolic)
Measured in millimiters of mercury (mmHg).
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Glycated haemoglobin (HbA1c) less than 7%
Measured as Yes/No.
Time frame: At end of follow-up (week 30 +- 4 weeks)
Reduction in glycated haemoglobin (HbA1c) greater than or equal to (>=) 1%
Measured as Yes/No.
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Weight loss >= 5%
Measured as Yes/No.
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Weight loss >= 3%
Measured as Yes/No.
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
HbA1c reduction >= 1% and weight loss of >=3%
Measured as Yes/No.
Time frame: From baseline (week 0) to end of follow-up (week 30+- 4 weeks)
Having at least 1 severe hypoglycaemic episode
Measured as Yes/No.
Time frame: At end of follow-up (week 30 +- 4 weeks)
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