Bioequivalence Study of 3 mg Glimepiride Tablet in Indonesia Healthy Subjects

Inclusion Criteria: * healthy male and female * had read the subject information and signed informed consent documents * were age between 18 to 55 years * had body mass index between 18 to 25 kg/m2 * had a normal electrocardiogram * had normal blood pressure (systolic was ranged between 90 to 120 mmHg and diastolic was ranged between 60 to 80 mmHg) * had normal heart rate (ranged between 60 to 100 bpm) * have no significant disease in medical history; have no significant abnormal values in laboratory and physical examination during screening * had acceptance to use protection (condom) during intercourse with their spouse throughout the study Exclusion Criteria: * Pregnant and/or nursing woman. * Those with a history of contraindication or hypersensitivity to glimepiride, other antidiabetic agent or other ingredients in the study products or a history of serious allergic reaction to any drug, significant allergic disease or allergic reaction. * Those with a history or presence of medical condition which might significantly influence the pharmacokinetics of the study drug, e.g. chronic gastrointestinal disease, diarrhea, gastric surgery, renal insufficiency, hepatic dysfunction or cardiovascular disease. * Those with a history or presence of any coagulation disorder or clinically significant hematology abnormalities. * Those who using any medication (prescription or non-prescription drug, food supplement, herbal medicine), particularly the medication known to affect the pharmacokinetic of the study drug, within one week prior to the drug administration day. * Those who had participated in any clinical study within 3 months prior to the study (\< 90 days). * Those who donated or lost 300 mL (or more) of blood within 3 months prior to the study. * Those who smoked more than 10 cigarettes a day * Those with a history of travelling to another city within the last 14 days * Those with a history of direct contact with a COVID-19 positive person in the subject's neighborhood * Those with a history or present of sore throat, fever (with temperature more than 37°C) or dyspnea within the last 14 days * Those who reactive to anti SARS CoV-2 test * Those who were positive to HIV, HBsAg, and HCV tests (to be kept confidential). * Those with a history of drug or alcohol abused within 12 months prior to screening for this study * Those who were unlikely to comply with the protocol, e.g uncooperative attitude, inability to return for follow up visits, poor venous access.