REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over the course of years to decades. Neuroplastic adaptations in the brain during the prodromal stage of disease are thought to mask the expression of motor and non-motor signs and may substantially delay diagnosis during a potentially critical time window. This study will examine the state and progression (over 30 to 36 months) of neuroplastic changes in the excitability of the motor and prefrontal cortex (using transcranial magnetic stimulation), the structural and functional connectivity of the brain (using highfield, 7T, magnetic resonance imaging), and the relationship of these changes to the expression of motor and neuropsychological signs, in a cohort of individuals with REM sleep behavior disorder and matched controls.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
86
Each subject will attend eight testing sessions (MRI scanning, two TMS-motor test visits, two TMS-prefrontal test visits, motor assessments, neuropsychological testing, and overnight sleep testing (polysomnography - PSG).
University of Minnesota
Minneapolis, Minnesota, United States
RECRUITINGMRI Progression over 30 to 36 months
Yes/No whether a change was observed from baseline
Time frame: 30 to 36 months from baseline
Change in Beck Depression Inventory score
Higher score means more impairment
Time frame: 30 to 36 months from baseline
Change in Mattis Dementia Rating Scale
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Rey Complex Figure
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in WAIS-IV Matrix Reasoning
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Stroop Color
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Stroop Word
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Stroop Color Word
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Wisconsin Card Sorting Test
Higher score means more impairment for subsections "# persev errors" and FMS; less impairment for subsections "# categories" and conceptualization
Time frame: 30 to 36 months from baseline
Change in D-KEFS
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in BVMT-R
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in HVLT
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in WMS-3 Spatial Span
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Boston Naming Test
Higher score means less impairment
Time frame: 30 to 36 months from baseline
Change in Trail Making Test A
Higher score means more impairment
Time frame: 30 to 36 months from baseline
Change in Trail Making Test B
Higher score means more impairment
Time frame: 30 to 36 months from baseline
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.